טוען...
Synthesis of selective inhibitors of sphingosine kinase 1
Sphingosine kinase isoform 1 (SK1) inhibitors may serve as therapeutic agents for proliferative diseases, including hypertension. We synthesized a series of sphingosine-based SK1-selective inhibitors, the most potent of which is RB-005 (IC(50) = 3.6 µM), which also induced proteasomal degradation of...
שמור ב:
| Main Authors: | , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2013
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3608193/ https://ncbi.nlm.nih.gov/pubmed/23388656 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3cc00181d |
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