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Snapshot of the equilibrium dynamics of a drug bound to HIV-1 reverse transcriptase
The anti-AIDS drug rilpivirine undergoes conformational changes to bind HIV-1 reverse transcriptase and retain potency against drug-resistance mutations. Our discovery that water molecules play an essential role in the drug binding is reported. Femtosecond experiments and theory expose molecular lev...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3607437/ https://ncbi.nlm.nih.gov/pubmed/23422558 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchem.1559 |
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