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A new class of isothiocyanate-based irreversible inhibitors of Macrophage Migration Inhibitory Factor (MIF)

Macrophage migration inhibitory factor (MIF) is a homotrimeric multifunctional proinflammatory cytokine that has been implicated in the pathogenesis of several inflammatory and autoimmune diseases. Current therapeutic strategies for targeting MIF focus on developing inhibitors of its tautomerase act...

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Detalhes bibliográficos
Main Authors: Ouertatani-Sakouhi, Hajer, El-Turk, Farah, Fauvet, Bruno, Roger, Thierry, Le Roy, Didier, Karpinar, Damla Pinar, Leng, Lin, Bucala, Richard, Zweckstetter, Markus, Calandra, Thierry, Lashuel, Hilal A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607106/
https://ncbi.nlm.nih.gov/pubmed/19737008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi900957e
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