Characterization of Molecular Determinants of the Conformational Stability of Macrophage Migration Inhibitory Factor: Leucine 46 Hydrophobic Pocket

Macrophage Migration Inhibitory Factor (MIF) is a key mediator of inflammatory responses and innate immunity and has been implicated in the pathogenesis of several inflammatory and autoimmune diseases. The oligomerization of MIF, more specifically trimer formation, is essential for its keto-enol tau...

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Bibliografiska uppgifter
Huvudupphovsmän: El-Turk, Farah, Fauvet, Bruno, Ashrafi, Amer, Ouertatani-Sakouhi, Hajer, Cho, Min-Kyu, Neri, Marilisa, Cascella, Michele, Rothlisberger, Ursula, Pojer, Florence, Zweckstetter, Markus, Lashuel, Hilal
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2012
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3448610/
https://ncbi.nlm.nih.gov/pubmed/23028743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045024
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