Identification and Characterization of Novel Classes of Macrophage Migration Inhibitory Factor (MIF) Inhibitors with Distinct Mechanisms of Action

Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine, is considered an attractive therapeutic target in multiple inflammatory and autoimmune disorders. In addition to its known biologic activities, MIF can also function as a tautomerase. Several small molecules have been reported...

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Библиографические подробности
Главные авторы: Ouertatani-Sakouhi, Hajer, El-Turk, Farah, Fauvet, Bruno, Cho, Min-Kyu, Pinar Karpinar, Damla, Le Roy, Didier, Dewor, Manfred, Roger, Thierry, Bernhagen, Jürgen, Calandra, Thierry, Zweckstetter, Markus, Lashuel, Hilal A.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2010
Предметы:
Protein Structure and Folding
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924096/
https://ncbi.nlm.nih.gov/pubmed/20516071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.113951
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