TLR4–MD-2 complex is negatively regulated by an endogenous ligand, globotetraosylceramide

Although endogenous ligands for Toll-like receptor (TLR)4–myeloid differentiation factor 2 (MD2) have not been well-understood, we here report that a globo-series glycosphingolipid, globotetraosylceramide (Gb4), attenuates the toxicity of lipopolysaccharides (LPSs) by binding to TLR4–MD-2. Because α...

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Autori principali: Kondo, Yuji, Ikeda, Kazutaka, Tokuda, Noriyo, Nishitani, Chiaki, Ohto, Umeharu, Akashi-Takamura, Sachiko, Ito, Yasutomo, Uchikawa, Makoto, Kuroki, Yoshio, Taguchi, Ryo, Miyake, Kensuke, Zhang, Qing, Furukawa, Keiko, Furukawa, Koichi
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2013
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607010/
https://ncbi.nlm.nih.gov/pubmed/23471986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218508110
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