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Structural Analyses of Human Toll-like Receptor 4 Polymorphisms D299G and T399I
Toll-like receptor 4 (TLR4) and its coreceptor MD-2 recognize bacterial lipopolysaccharide (LPS) and signal the innate immune response. Two single nucleotide polymorphisms (SNPs) of human TLR4, D299G and T399I, have been identified and suggested to be associated with LPS hyporesponsiveness. Moreover...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3504774/ https://ncbi.nlm.nih.gov/pubmed/23055527 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.404608 |
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