Structural Analyses of Human Toll-like Receptor 4 Polymorphisms D299G and T399I

Toll-like receptor 4 (TLR4) and its coreceptor MD-2 recognize bacterial lipopolysaccharide (LPS) and signal the innate immune response. Two single nucleotide polymorphisms (SNPs) of human TLR4, D299G and T399I, have been identified and suggested to be associated with LPS hyporesponsiveness. Moreover...

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Bibliografiske detaljer
Main Authors: Ohto, Umeharu, Yamakawa, Natsuko, Akashi-Takamura, Sachiko, Miyake, Kensuke, Shimizu, Toshiyuki
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3504774/
https://ncbi.nlm.nih.gov/pubmed/23055527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.404608
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