Structural Analyses of Human Toll-like Receptor 4 Polymorphisms D299G and T399I

Toll-like receptor 4 (TLR4) and its coreceptor MD-2 recognize bacterial lipopolysaccharide (LPS) and signal the innate immune response. Two single nucleotide polymorphisms (SNPs) of human TLR4, D299G and T399I, have been identified and suggested to be associated with LPS hyporesponsiveness. Moreover...

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Bibliografiset tiedot
Päätekijät: Ohto, Umeharu, Yamakawa, Natsuko, Akashi-Takamura, Sachiko, Miyake, Kensuke, Shimizu, Toshiyuki
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2012
Aiheet:
Protein Structure and Folding
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3504774/
https://ncbi.nlm.nih.gov/pubmed/23055527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.404608
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