Guanosine and its modified derivatives are endogenous ligands for TLR7

Toll-like receptor (TLR) 7and 8 were considered to recognize single-strand RNA (ssRNA) from viruses. Although these receptors also respond to synthetic small chemical ligands, such as CL075 and R848, it remains to be determined whether these receptors sense natural small molecules or not. In the str...

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Vydáno v:Int Immunol
Hlavní autoři: Shibata, Takuma, Ohto, Umeharu, Nomura, Shosaku, Kibata, Kayoko, Motoi, Yuji, Zhang, Yan, Murakami, Yusuke, Fukui, Ryutaro, Ishimoto, Tatsushi, Sano, Shigetoshi, Ito, Tomoki, Shimizu, Toshiyuki, Miyake, Kensuke
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4888345/
https://ncbi.nlm.nih.gov/pubmed/26489884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/intimm/dxv062
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