Murine thymic selection quantified using a unique method to capture deleted T cells

Thymic positive and negative selection events generate a T-cell repertoire that is MHC restricted and self-tolerant. The number of T cells undergoing positive and negative selection in normal mice has never been firmly established. We generated mice that lack the proapoptotic molecule Bim (bcl2l11)...

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Bibliographic Details
Main Authors: Stritesky, Gretta L., Xing, Yan, Erickson, Jami R., Kalekar, Lokesh A., Wang, Xiaodan, Mueller, Daniel L., Jameson, Stephen C., Hogquist, Kristin A.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2013
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3606987/
https://ncbi.nlm.nih.gov/pubmed/23487759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1217532110
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