αB-crystallin stimulates VEGF secretion and tumor cell migration and correlates with enhanced distant metastasis in head and neck squamous cell carcinoma

BACKGROUND: αB-crystallin is able to modulate vascular endothelial growth factor (VEGF) secretion. In many solid tumors VEGF is associated with angiogenesis, metastasis formation and poor prognosis. We set out to assess whether αB-crystallin expression is correlated with worse prognosis and whether...

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Bibliografske podrobnosti
Main Authors: van de Schootbrugge, Chantal, Bussink, Johan, Span, Paul N, Sweep, Fred CGJ, Grénman, Reidar, Stegeman, Hanneke, Pruijn, Ger JM, Kaanders, Johannes HAM, Boelens, Wilbert C
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3606599/
https://ncbi.nlm.nih.gov/pubmed/23506259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-128
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