αB-crystallin stimulates VEGF secretion and tumor cell migration and correlates with enhanced distant metastasis in head and neck squamous cell carcinoma

BACKGROUND: αB-crystallin is able to modulate vascular endothelial growth factor (VEGF) secretion. In many solid tumors VEGF is associated with angiogenesis, metastasis formation and poor prognosis. We set out to assess whether αB-crystallin expression is correlated with worse prognosis and whether...

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Hauptverfasser: van de Schootbrugge, Chantal, Bussink, Johan, Span, Paul N, Sweep, Fred CGJ, Grénman, Reidar, Stegeman, Hanneke, Pruijn, Ger JM, Kaanders, Johannes HAM, Boelens, Wilbert C
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3606599/
https://ncbi.nlm.nih.gov/pubmed/23506259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-128
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