αB-crystallin stimulates VEGF secretion and tumor cell migration and correlates with enhanced distant metastasis in head and neck squamous cell carcinoma

BACKGROUND: αB-crystallin is able to modulate vascular endothelial growth factor (VEGF) secretion. In many solid tumors VEGF is associated with angiogenesis, metastasis formation and poor prognosis. We set out to assess whether αB-crystallin expression is correlated with worse prognosis and whether...

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Detalhes bibliográficos
Main Authors: van de Schootbrugge, Chantal, Bussink, Johan, Span, Paul N, Sweep, Fred CGJ, Grénman, Reidar, Stegeman, Hanneke, Pruijn, Ger JM, Kaanders, Johannes HAM, Boelens, Wilbert C
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3606599/
https://ncbi.nlm.nih.gov/pubmed/23506259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-128
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