A modified HSP70 inhibitor shows broad activity as an anticancer agent

The stress-induced heat shock protein 70 (HSP70) is an ATP-dependent molecular chaperone that plays a key role in refolding misfolded proteins and promoting cell survival following stress. HSP70 is marginally expressed in non-transformed cells, but is greatly overexpressed in tumor cells. Silencing...

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Autores principales: Balaburski, Gregor M., Leu, Julia I-Ju, Beeharry, Neil, Hayik, Seth, Andrake, Mark D., Zhang, Gao, Herlyn, Meenhard, Villanueva, Jessie, Dunbrack, Roland L., Yen, Tim, George, Donna L., Murphy, Maureen E.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3606282/
https://ncbi.nlm.nih.gov/pubmed/23303345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-12-0547-T
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