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Comparison of the activity of three different HSP70 inhibitors on apoptosis, cell cycle arrest, autophagy inhibition, and HSP90 inhibition

The chaperone HSP70 promotes the survival of cells exposed to many different types of stresses, and is also potently anti-apoptotic. The major stress-induced form of this protein, HSP70–1, is overexpressed in a number of human cancers, yet is negligibly expressed in normal cells. Silencing of the ge...

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Autors principals: Budina-Kolomets, Anna, Balaburski, Gregor M, Bondar, Anastasia, Beeharry, Neil, Yen, Tim, Murphy, Maureen E
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3928135/
https://ncbi.nlm.nih.gov/pubmed/24100579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.26720
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