A fully humanized transgenic mouse model of Huntington disease

Silencing the mutant huntingtin gene (muHTT) is a direct and simple therapeutic strategy for the treatment of Huntington disease (HD) in principle. However, targeting the HD mutation presents challenges because it is an expansion of a common genetic element (a CAG tract) that is found throughout the...

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Detalhes bibliográficos
Main Authors: Southwell, Amber L., Warby, Simon C., Carroll, Jeffrey B., Doty, Crystal N., Skotte, Niels H., Zhang, Weining, Villanueva, Erika B., Kovalik, Vlad, Xie, Yuanyun, Pouladi, Mahmoud A., Collins, Jennifer A., Yang, X. William, Franciosi, Sonia, Hayden, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3606012/
https://ncbi.nlm.nih.gov/pubmed/23001568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds397
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