A fully humanized transgenic mouse model of Huntington disease

Silencing the mutant huntingtin gene (muHTT) is a direct and simple therapeutic strategy for the treatment of Huntington disease (HD) in principle. However, targeting the HD mutation presents challenges because it is an expansion of a common genetic element (a CAG tract) that is found throughout the...

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Bibliografski detalji
Glavni autori: Southwell, Amber L., Warby, Simon C., Carroll, Jeffrey B., Doty, Crystal N., Skotte, Niels H., Zhang, Weining, Villanueva, Erika B., Kovalik, Vlad, Xie, Yuanyun, Pouladi, Mahmoud A., Collins, Jennifer A., Yang, X. William, Franciosi, Sonia, Hayden, Michael R.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2013
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Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3606012/
https://ncbi.nlm.nih.gov/pubmed/23001568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds397
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