A fully humanized transgenic mouse model of Huntington disease

Silencing the mutant huntingtin gene (muHTT) is a direct and simple therapeutic strategy for the treatment of Huntington disease (HD) in principle. However, targeting the HD mutation presents challenges because it is an expansion of a common genetic element (a CAG tract) that is found throughout the...

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Bibliografiset tiedot
Päätekijät: Southwell, Amber L., Warby, Simon C., Carroll, Jeffrey B., Doty, Crystal N., Skotte, Niels H., Zhang, Weining, Villanueva, Erika B., Kovalik, Vlad, Xie, Yuanyun, Pouladi, Mahmoud A., Collins, Jennifer A., Yang, X. William, Franciosi, Sonia, Hayden, Michael R.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2013
Aiheet:
Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3606012/
https://ncbi.nlm.nih.gov/pubmed/23001568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds397
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