Tripartite Motif Ligases Catalyze Polyubiquitin Chain Formation through a Cooperative Allosteric Mechanism

Ligation of polyubiquitin chains to proteins is a fundamental post-translational modification, often resulting in targeted degradation of conjugated proteins. Attachment of polyubiquitin chains requires the activities of an E1 activating enzyme, an E2 carrier protein, and an E3 ligase. The mechanism...

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Detalhes bibliográficos
Main Authors: Streich, Frederick C., Ronchi, Virginia P., Connick, J. Patrick, Haas, Arthur L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605639/
https://ncbi.nlm.nih.gov/pubmed/23408431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.451567
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