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In silico modeling of the cryptic E2∼ubiquitin–binding site of E6-associated protein (E6AP)/UBE3A reveals the mechanism of polyubiquitin chain assembly
To understand the mechanism for assembly of Lys(48)-linked polyubiquitin degradation signals, we previously demonstrated that the E6AP/UBE3A ligase harbors two functionally distinct E2∼ubiquitin–binding sites: a high-affinity Site 1 required for E6AP Cys(820)∼ubiquitin thioester formation and a cano...
Gorde:
| Argitaratua izan da: | J Biol Chem |
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| Egile Nagusiak: | , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
American Society for Biochemistry and Molecular Biology
2017
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5672028/ https://ncbi.nlm.nih.gov/pubmed/28924046 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.813477 |
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