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Oligomerization of the HECT ubiquitin ligase NEDD4-2/NEDD4L is essential for polyubiquitin chain assembly

The NEDD4-2 (neural precursor cell–expressed developmentally down-regulated 4-2) HECT ligase catalyzes polyubiquitin chain assembly by an ordered two-step mechanism requiring two functionally distinct E2∼ubiquitin–binding sites, analogous to the trimeric E6AP/UBE3A HECT ligase. This conserved cataly...

詳細記述

保存先:
書誌詳細
出版年:J Biol Chem
主要な著者: Todaro, Dustin R., Augustus-Wallace, Allison C., Klein, Jennifer M., Haas, Arthur L.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6254339/
https://ncbi.nlm.nih.gov/pubmed/30287686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003716
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