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The Active Form of E6-associated protein (E6AP)/UBE3A Ubiquitin Ligase Is an Oligomer

Employing (125)I-polyubiquitin chain formation as a functional readout of ligase activity, biochemical and biophysical evidence demonstrates that catalytically active E6-associated protein (E6AP)/UBE3A is an oligomer. Based on an extant structure previously discounted as an artifact of crystal packi...

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Autors principals: Ronchi, Virginia P., Klein, Jennifer M., Edwards, Daniel J., Haas, Arthur L.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887172/
https://ncbi.nlm.nih.gov/pubmed/24273172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.517805
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