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The Active Form of E6-associated protein (E6AP)/UBE3A Ubiquitin Ligase Is an Oligomer
Employing (125)I-polyubiquitin chain formation as a functional readout of ligase activity, biochemical and biophysical evidence demonstrates that catalytically active E6-associated protein (E6AP)/UBE3A is an oligomer. Based on an extant structure previously discounted as an artifact of crystal packi...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3887172/ https://ncbi.nlm.nih.gov/pubmed/24273172 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.517805 |
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