Tripartite Motif Ligases Catalyze Polyubiquitin Chain Formation through a Cooperative Allosteric Mechanism

Ligation of polyubiquitin chains to proteins is a fundamental post-translational modification, often resulting in targeted degradation of conjugated proteins. Attachment of polyubiquitin chains requires the activities of an E1 activating enzyme, an E2 carrier protein, and an E3 ligase. The mechanism...

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Autors principals: Streich, Frederick C., Ronchi, Virginia P., Connick, J. Patrick, Haas, Arthur L.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Enzymology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605639/
https://ncbi.nlm.nih.gov/pubmed/23408431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.451567
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