Tripartite Motif Ligases Catalyze Polyubiquitin Chain Formation through a Cooperative Allosteric Mechanism

Ligation of polyubiquitin chains to proteins is a fundamental post-translational modification, often resulting in targeted degradation of conjugated proteins. Attachment of polyubiquitin chains requires the activities of an E1 activating enzyme, an E2 carrier protein, and an E3 ligase. The mechanism...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Streich, Frederick C., Ronchi, Virginia P., Connick, J. Patrick, Haas, Arthur L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Enzymology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605639/
https://ncbi.nlm.nih.gov/pubmed/23408431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.451567
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares