Structure of the Human Angiotensin II Type 1 (AT(1)) Receptor Bound to Angiotensin II from Multiple Chemoselective Photoprobe Contacts Reveals a Unique Peptide Binding Mode

Breakthroughs in G protein-coupled receptor structure determination based on crystallography have been mainly obtained from receptors occupied in their transmembrane domain core by low molecular weight ligands, and we have only recently begun to elucidate how the extracellular surface of G protein-c...

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Autores principales: Fillion, Dany, Cabana, Jérôme, Guillemette, Gaétan, Leduc, Richard, Lavigne, Pierre, Escher, Emanuel
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Protein Structure and Folding
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605637/
https://ncbi.nlm.nih.gov/pubmed/23386604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.442053
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