Critical Hydrogen Bond Formation for Activation of the Angiotensin II Type 1 Receptor

G protein-coupled receptors contain selectively important residues that play central roles in the conformational changes that occur during receptor activation. Asparagine 111 (N111(3.35)) is such a residue within the angiotensin II type 1 (AT(1)) receptor. Substitution of N111(3.35) for glycine lead...

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Autores principales: Cabana, Jérôme, Holleran, Brian, Beaulieu, Marie-Ève, Leduc, Richard, Escher, Emanuel, Guillemette, Gaétan, Lavigne, Pierre
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Computational Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554926/
https://ncbi.nlm.nih.gov/pubmed/23223579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.395939
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