Identification of Distinct Conformations of the Angiotensin-II Type 1 Receptor Associated with the G(q/11) Protein Pathway and the β-Arrestin Pathway Using Molecular Dynamics Simulations

Biased signaling represents the ability of G protein-coupled receptors to engage distinct pathways with various efficacies depending on the ligand used or on mutations in the receptor. The angiotensin-II type 1 (AT(1)) receptor, a prototypical class A G protein-coupled receptor, can activate various...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Cabana, Jérôme, Holleran, Brian, Leduc, Richard, Escher, Emanuel, Guillemette, Gaétan, Lavigne, Pierre
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2015
Sujets:
Computational Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505491/
https://ncbi.nlm.nih.gov/pubmed/25934394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.627356
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