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Identification of Distinct Conformations of the Angiotensin-II Type 1 Receptor Associated with the G(q/11) Protein Pathway and the β-Arrestin Pathway Using Molecular Dynamics Simulations
Biased signaling represents the ability of G protein-coupled receptors to engage distinct pathways with various efficacies depending on the ligand used or on mutations in the receptor. The angiotensin-II type 1 (AT(1)) receptor, a prototypical class A G protein-coupled receptor, can activate various...
Shranjeno v:
| izdano v: | J Biol Chem |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2015
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4505491/ https://ncbi.nlm.nih.gov/pubmed/25934394 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.627356 |
| Oznake: |
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