Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice

The principal reason for failure of targeted cancer therapies is the emergence of resistant clones that regenerate the tumor. Therapeutic efficacy therefore depends on not only how effectively a drug inhibits its target, but also the innate or adaptive functional redundancy of that target and its at...

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Bibliographic Details
Main Authors: Soucek, Laura, Whitfield, Jonathan R., Sodir, Nicole M., Massó-Vallés, Daniel, Serrano, Erika, Karnezis, Anthony N., Swigart, Lamorna Brown, Evan, Gerard I.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2013
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605464/
https://ncbi.nlm.nih.gov/pubmed/23475959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.205542.112
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