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The lysine deacetylase inhibitor givinostat inhibits β-cell IL-1β induced IL-1β transcription and processing
Aims: Pro-inflammatory cytokines and chemokines, in particular IL-1β, IFNγ, and CXCL10, contribute to β-cell failure and loss in DM via IL-1R, IFNγR, and TLR4 signaling. IL-1 signaling deficiency reduces diabetes incidence, islet IL-1β secretion, and hyperglycemia in animal models of diabetes. Furth...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3605170/ https://ncbi.nlm.nih.gov/pubmed/23486342 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/isl.23541 |
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