Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and β-cell protection

Type 1 diabetes is due to destruction of pancreatic β-cells. Lysine deacetylase inhibitors (KDACi) protect β-cells from inflammatory destruction in vitro and are promising immunomodulators. Here we demonstrate that the clinically well-tolerated KDACi vorinostat and givinostat revert diabetes in the...

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Detalhes bibliográficos
Main Authors: Christensen, Dan Ploug, Gysemans, Conny, Lundh, Morten, Dahllöf, Mattias Salling, Noesgaard, Daniel, Schmidt, Søren Fisker, Mandrup, Susanne, Birkbak, Nikolai, Workman, Christopher T., Piemonti, Lorenzo, Blaabjerg, Lykke, Monzani, Valmen, Fossati, Gianluca, Mascagni, Paolo, Paraskevas, Steven, Aikin, Reid A., Billestrup, Nils, Grunnet, Lars Groth, Dinarello, Charles A., Mathieu, Chantal, Mandrup-Poulsen, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3903225/
https://ncbi.nlm.nih.gov/pubmed/24395784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1320850111
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