Proinflammatory Cytokines Activate the Intrinsic Apoptotic Pathway in β-Cells

OBJECTIVE: Proinflammatory cytokines are cytotoxic to β-cells and have been implicated in the pathogenesis of type 1 diabetes and islet graft failure. The importance of the intrinsic mitochondrial apoptotic pathway in cytokine-induced β-cell death is unclear. Here, cytokine activation of the intrins...

Ausführliche Beschreibung

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Hauptverfasser: Grunnet, Lars G., Aikin, Reid, Tonnesen, Morten F., Paraskevas, Steven, Blaabjerg, Lykke, Størling, Joachim, Rosenberg, Lawrence, Billestrup, Nils, Maysinger, Dusica, Mandrup-Poulsen, Thomas
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Diabetes Association 2009
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2712790/
https://ncbi.nlm.nih.gov/pubmed/19470609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0178
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