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Modulation of JNK and p38 Stress Activated Protein Kinases In Isolated Islets of Langerhans: Insulin as an Autocrine Survival Signal

OBJECTIVE: The objective of this study was to determine the effects of islet isolation and cytokine exposure on e-JUN NH(2) terminal kinase (JNK) and p38 activation and whether insulin or the p38 inhibitor PD169316 could modify the response. SUMMARY BACKGROUND DATA: Islet transplantation exposes the...

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Detalhes bibliográficos
Main Authors: Paraskevas, Steven, Aikin, Reid, Maysinger, Dusica, Lakey, Jonathan R.T., Cavanagh, Thomas J., Agapitos, Despina, Wang, Rennian, Rosenberg, Lawrence
Formato: Artigo
Idioma:Inglês
Publicado em: 2001
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1421175/
https://ncbi.nlm.nih.gov/pubmed/11141234
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