JNK1 Deficient Insulin-Producing Cells Are Protected against Interleukin-1β-Induced Apoptosis Associated with Abrogated Myc Expression

The relative contributions of the JNK subtypes in inflammatory β-cell failure and apoptosis are unclear. The JNK protein family consists of JNK1, JNK2, and JNK3 subtypes, encompassing many different isoforms. INS-1 cells express JNK1α1, JNK1α2, JNK1β1, JNK1β2, JNK2α1, JNK2α2, JNK3α1, and JNK3α2 mRNA...

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Detalhes bibliográficos
Publicado no:J Diabetes Res
Main Authors: Prause, Michala, Mayer, Christopher Michael, Brorsson, Caroline, Frederiksen, Klaus Stensgaard, Billestrup, Nils, Størling, Joachim, Mandrup-Poulsen, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4745310/
https://ncbi.nlm.nih.gov/pubmed/26962537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/1312705
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