Identification of Novel Type 1 Diabetes Candidate Genes by Integrating Genome-Wide Association Data, Protein-Protein Interactions, and Human Pancreatic Islet Gene Expression

Genome-wide association studies (GWAS) have heralded a new era in susceptibility locus discovery in complex diseases. For type 1 diabetes, >40 susceptibility loci have been discovered. However, GWAS do not inevitably lead to identification of the gene or genes in a given locus associated with dis...

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Autores principales: Bergholdt, Regine, Brorsson, Caroline, Palleja, Albert, Berchtold, Lukas A., Fløyel, Tina, Bang-Berthelsen, Claus Heiner, Frederiksen, Klaus Stensgaard, Jensen, Lars Juhl, Størling, Joachim, Pociot, Flemming
Formato: Artigo
Lenguaje:Inglês
Publicado: American Diabetes Association 2012
Materias:
Genetics/Genomes/Proteomics/Metabolomics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314366/
https://ncbi.nlm.nih.gov/pubmed/22344559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-1263
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