The lysine deacetylase inhibitor givinostat inhibits β-cell IL-1β induced IL-1β transcription and processing

Aims: Pro-inflammatory cytokines and chemokines, in particular IL-1β, IFNγ, and CXCL10, contribute to β-cell failure and loss in DM via IL-1R, IFNγR, and TLR4 signaling. IL-1 signaling deficiency reduces diabetes incidence, islet IL-1β secretion, and hyperglycemia in animal models of diabetes. Furth...

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Détails bibliographiques
Auteurs principaux: Dahllöf, Mattias S., Christensen, Dan P., Lundh, Morten, Dinarello, Charles A., Mascagni, Paolo, Grunnet, Lars G., Mandrup-Poulsen, Thomas
Format: Artigo
Langue:Inglês
Publié: Landes Bioscience 2012
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605170/
https://ncbi.nlm.nih.gov/pubmed/23486342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/isl.23541
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