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Age-related oxidative modifications of transthyretin modulate its amyloidogenicity

The transthyretin amyloidoses are diseases of protein misfolding characterized by the extracellular deposition of fibrils and other aggregates of the homotetrameric protein transthyretin (TTR) in peripheral nerves, heart and other tissues. Age is the major risk factor for the development of these di...

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Détails bibliographiques
Auteurs principaux: Zhao, Lei, Buxbaum, Joel N, Reixach, Natàlia
Format: Artigo
Langue:Inglês
Publié: 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3604100/
https://ncbi.nlm.nih.gov/pubmed/23414091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301313b
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