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Lineage-specific functions of Bcl-6 in immunity and inflammation are mediated through distinct biochemical mechanisms
The transcription factor Bcl-6 orchestrates the germinal center reaction through its actions in B and T cells, and regulates inflammatory signaling in macrophages. We report that genetic replacement by mutant Bcl-6, which cannot bind corepressors to its BTB domain, disrupted germinal center formatio...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3604075/ https://ncbi.nlm.nih.gov/pubmed/23455674 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2543 |
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