Coupling endonucleases with DNA end-processing enzymes to drive gene disruption

Targeted DNA double-strand breaks introduced by rare-cleaving designer endonucleases can be harnessed for gene disruption applications by engaging mutagenic nonhomologous end-joining DNA repair pathways. However, endonuclease-mediated DNA breaks are often subject to precise repair, which limits the...

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Autori principali: Certo, Michael T, Gwiazda, Kamila S, Kuhar, Ryan, Sather, Blythe, Curinga, Gabrielle, Mandt, Tyler, Brault, Michelle, Lambert, Abigail R, Baxter, Sarah K, Jacoby, Kyle, Ryu, Byoung Y, Kiem, Hans-Peter, Gouble, Agnes, Paques, Frederic, Rawlings, David J, Scharenberg, Andrew M
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602999/
https://ncbi.nlm.nih.gov/pubmed/22941364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.2177
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