Bradycardia alters Ca(2+) dynamics enhancing dispersion of repolarization and arrhythmia risk

Bradycardia prolongs action potential (AP) durations (APD adaptation), enhances dispersion of repolarization (DOR), and promotes tachyarrhythmias. Yet, the mechanisms responsible for enhanced DOR and tachyarrhythmias remain largely unexplored. Ca(2+) transients and APs were measured optically from L...

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Détails bibliographiques
Auteurs principaux: Kim, Jong J., Němec, Jan, Papp, Rita, Strongin, Robert, Abramson, Jonathan J., Salama, Guy
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2013
Sujets:
Cardiac Excitation and Contraction
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602772/
https://ncbi.nlm.nih.gov/pubmed/23316064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00787.2012
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