Dispersion of repolarization and refractoriness are determinants of arrhythmia phenotype in transgenic mice with long QT

Enhanced dispersion of repolarization (DR) and refractoriness may be a unifying mechanism central to arrhythmia genesis in the long QT (LQT) syndrome. The role of DR in promoting arrhythmias was investigated in several strains of molecularly engineered mice: (a) Kv4.2 dominant negative transgenic (K...

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Main Authors: London, Barry, Baker, Linda C, Petkova-Kirova, Polina, Nerbonne, Jeanne M, Choi, Bum-Rak, Salama, Guy
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2075135/
https://ncbi.nlm.nih.gov/pubmed/17110412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2006.122622
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