IL-17 induces type V collagen overexpression and EMT via TGF-β-dependent pathways in obliterative bronchiolitis

Obliterative bronchiolitis (OB), a fibrotic airway lesion, is the leading cause of death after lung transplantation. Type V collagen [col(V)] overexpression and IL-17-mediated anti-col(V) immunity are key contributors to OB pathogenesis. Here, we report a previously undefined role of IL-17 in induci...

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Main Authors: Vittal, Ragini, Fan, Lin, Greenspan, Daniel S., Mickler, Elizabeth A., Gopalakrishnan, Bagavathi, Gu, Hongmei, Benson, Heather L., Zhang, Chen, Burlingham, William, Cummings, Oscar W., Wilkes, David S.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2013
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602743/
https://ncbi.nlm.nih.gov/pubmed/23262228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00080.2012
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