Ghrelin Restoration of Function In Vitro in Somatotropes from Male Mice Lacking the Janus Kinase (JAK)-Binding Site of the Leptin Receptor

Deletion of the signaling domain of leptin receptors selectively in somatotropes, with Cre-loxP technology, reduced the percentage of immunolabeled GH cells and serum GH. We hypothesized that the deficit occurred when leptin's postnatal surge failed to stimulate an expansion in the cell populat...

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Autors principals: Syed, Mohsin, Cozart, Michael, Haney, Anessa C., Akhter, Noor, Odle, Angela K., Allensworth-James, Melody, Crane, Christopher, Syed, Farhan M., Childs, Gwen V.
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2013
Matèries:
Growth Hormone-Somatostatin-GRH
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602631/
https://ncbi.nlm.nih.gov/pubmed/23417423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2012-2254
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