Ghrelin Restoration of Function In Vitro in Somatotropes from Male Mice Lacking the Janus Kinase (JAK)-Binding Site of the Leptin Receptor

Deletion of the signaling domain of leptin receptors selectively in somatotropes, with Cre-loxP technology, reduced the percentage of immunolabeled GH cells and serum GH. We hypothesized that the deficit occurred when leptin's postnatal surge failed to stimulate an expansion in the cell populat...

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Main Authors: Syed, Mohsin, Cozart, Michael, Haney, Anessa C., Akhter, Noor, Odle, Angela K., Allensworth-James, Melody, Crane, Christopher, Syed, Farhan M., Childs, Gwen V.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2013
Assuntos:
Growth Hormone-Somatostatin-GRH
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602631/
https://ncbi.nlm.nih.gov/pubmed/23417423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2012-2254
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