Ghrelin Restoration of Function In Vitro in Somatotropes from Male Mice Lacking the Janus Kinase (JAK)-Binding Site of the Leptin Receptor

Deletion of the signaling domain of leptin receptors selectively in somatotropes, with Cre-loxP technology, reduced the percentage of immunolabeled GH cells and serum GH. We hypothesized that the deficit occurred when leptin's postnatal surge failed to stimulate an expansion in the cell populat...

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Главные авторы: Syed, Mohsin, Cozart, Michael, Haney, Anessa C., Akhter, Noor, Odle, Angela K., Allensworth-James, Melody, Crane, Christopher, Syed, Farhan M., Childs, Gwen V.
Формат: Artigo
Язык:Inglês
Опубликовано: Endocrine Society 2013
Предметы:
Growth Hormone-Somatostatin-GRH
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602631/
https://ncbi.nlm.nih.gov/pubmed/23417423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2012-2254
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