Ablation of Leptin Signaling to Somatotropes: Changes in Metabolic Factors that Cause Obesity

Mice with somatotrope-specific deletion of the Janus kinase binding site in leptin receptors are GH deficient as young adults and become obese by 6 months of age. This study focused on the metabolic status of young (3–4.5 month old) preobese mutant mice. These mutants had normal body weights, lean b...

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Hauptverfasser: Akhter, Noor, Odle, Angela K., Allensworth-James, Melody L., Haney, Anessa C., Syed, Mohsin M., Cozart, Michael A., Chua, Streamson, Kineman, Rhonda, Childs, Gwen V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Endocrine Society 2012
Schlagworte:
Energy Balance-Obesity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3512011/
https://ncbi.nlm.nih.gov/pubmed/22865370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2012-1331
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