Sex Differences in Somatotrope Dependency on Leptin Receptors in Young Mice: Ablation of LEPR Causes Severe Growth Hormone Deficiency and Abdominal Obesity in Males

Leptin receptor (LEPR) signaling controls appetite and energy expenditure. Somatotrope-specific deletion of the LEPRb signaling isoform causes GH deficiency and obesity. The present study selectively ablated Lepr exon 1 in somatotropes, which removes the signal peptide, causing the loss of all isofo...

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Veröffentlicht in:Endocrinology
Hauptverfasser: Allensworth-James, Melody L., Odle, Angela, Haney, Anessa, Childs, Gwen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Endocrine Society 2015
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4541611/
https://ncbi.nlm.nih.gov/pubmed/26168341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/EN.2015-1198
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