Toll-like receptor 9 interaction with CpG ODN – An in silico analysis approach

BACKGROUND: Toll-like receptor 9 (TLR9) recognises unmethylated CpG DNA and activates a signalling cascade, leading to the production of inflammatory cytokines such as TNF-α, IL-1, IL-6 and IL-12 via the adaptor protein MyD88. However, the specific sequence and structural requirements of the CpG DNA...

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Detalhes bibliográficos
Main Authors: Zhou, Wei, Li, Yan, Pan, Xichun, Gao, Yuan, Li, Beiping, Qiu, Zhengliang, Liang, Long, Zhou, Hong, Yue, Junjie
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602074/
https://ncbi.nlm.nih.gov/pubmed/23497207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4682-10-18
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