Leucine-rich Repeat 11 of Toll-like Receptor 9 Can Tightly Bind to CpG-containing Oligodeoxynucleotides, and the Positively Charged Residues Are Critical for the High Affinity

TLR9 is a receptor for sensing bacterial DNA/CpG-containing oligonucleotides (CpG ODN). The extracellular domain (ECD) of human TLR9 (hTLR9) is composed of 25 leucine-rich repeats (LRR) contributing to the binding of CpG ODN. Herein, we showed that among LRR2, -5, -8, and -11, LRR11 of hTLR9 had the...

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Detalhes bibliográficos
Main Authors: Pan, Xichun, Yue, Junjie, Ding, Guofu, Li, Bin, Liu, Xin, Zheng, Xinchuan, Yu, Mengchen, Li, Jun, Jiang, Weiwei, Wu, Chong, Zheng, Jiang, Zhou, Hong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436306/
https://ncbi.nlm.nih.gov/pubmed/22822061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.396432
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