Proinflammatory Stimulation of Toll-Like Receptor 9 with High Dose CpG ODN 1826 Impairs Endothelial Regeneration and Promotes Atherosclerosis in Mice

BACKGROUND: Toll-like receptors (TLR) of the innate immune system have been closely linked with the development of atherosclerotic lesions. TLR9 is activated by unmethylated CpG motifs within ssDNA, but also by CpG motifs in nucleic acids released during vascular apoptosis and necrosis. The role of...

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Bibliografski detalji
Izdano u:PLoS One
Glavni autori: Krogmann, Alexander O., Lüsebrink, Enzo, Steinmetz, Martin, Asdonk, Tobias, Lahrmann, Catharina, Lütjohann, Dieter, Nickenig, Georg, Zimmer, Sebastian
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2016
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4709087/
https://ncbi.nlm.nih.gov/pubmed/26751387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0146326
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