Proinflammatory Stimulation of Toll-Like Receptor 9 with High Dose CpG ODN 1826 Impairs Endothelial Regeneration and Promotes Atherosclerosis in Mice

BACKGROUND: Toll-like receptors (TLR) of the innate immune system have been closely linked with the development of atherosclerotic lesions. TLR9 is activated by unmethylated CpG motifs within ssDNA, but also by CpG motifs in nucleic acids released during vascular apoptosis and necrosis. The role of...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Krogmann, Alexander O., Lüsebrink, Enzo, Steinmetz, Martin, Asdonk, Tobias, Lahrmann, Catharina, Lütjohann, Dieter, Nickenig, Georg, Zimmer, Sebastian
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4709087/
https://ncbi.nlm.nih.gov/pubmed/26751387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0146326
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi