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Special delivery: granulin brings CpG DNA to Toll-like receptor 9

Foreign DNA activates the innate immune response through Toll-like receptor 9 (TLR9). In this issue of Immunity, Park et al (2011). present evidence that granulin is a cofactor for TLR9 activation, delivering CpG-oligodeoxynucleotides to TLR9 in endolysosomes.

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Detalhes bibliográficos
Main Authors: Moresco, Eva Marie Y., Beutler, Bruce
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093957/
https://ncbi.nlm.nih.gov/pubmed/21511177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2011.04.001
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