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Special delivery: granulin brings CpG DNA to Toll-like receptor 9
Foreign DNA activates the innate immune response through Toll-like receptor 9 (TLR9). In this issue of Immunity, Park et al (2011). present evidence that granulin is a cofactor for TLR9 activation, delivering CpG-oligodeoxynucleotides to TLR9 in endolysosomes.
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3093957/ https://ncbi.nlm.nih.gov/pubmed/21511177 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2011.04.001 |
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